The S. thermophilus LMG18311 glass MicroArrays were developed in collaboration with Prof. Jean Delcour and Dr. Pascal Hols, Université catolique de Louvain (UCL) for more information please visit the following link http://www.biol.ucl.ac.be/gene/genome/postgenomics_bioinfo.html.
The complete sequence of the S. thermophilus genome, together with its related post-genomics tools (DNA microarrays), offers unique opportunities to study the metabolism of this microorganism .
DNA microarrays are currently used to study the functional role of global regulation circuits in carbon metabolism at the transcriptional level (collaboration with Dr. P. Hols (UCL) and E. Guédon and P. Renault (INRA, France).
A first investigation concerns the functional role of CcpA involved in carbon catabolite repression, which plays an important role in controlling glycolysis and pyruvate dissipating pathways.
Future work will also exploit this tool for studying transcriptional regulation mediated by environmental parameters important for metabolism adaptation such as O2, pH, redox balance, sugar source…
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The use of this Array-related product in relation to the manufacture or use of nucleic acid arrays may be covered by the following patent owned by Oxford Gene Technology Limited ("OGT"): EP 0,373,203. The purchase of this product does not confer on the purchaser any rights or licences under any OGT patent. To enquire about a licence under OGT's patents, please contact licensing@ogt.co.uk.