Advantages of DNA Vaccines
This non-viral approach offers a number of advantages over traditional small molecule therapeutic methods and viral gene therapy methods.
DNA vaccines offer multiple mechanisms of action including to:
- use the body's immune system by producing the antigen in situ
- or produce supraphysiologic amounts of an endogenous therapeutic protein
- include the desired mammalian post-translational modifications
- improved pharmacokinetic properties compared to intravenously administered protein
- or deliver therapeutic siRNA (small interfering RNA) including shRNA (small hairping RNAs)
- can be manufactured more easily, faster and in larger scale than alternatives
- excellent storage properties
Numerous Routes of Administration
- Needle injection
- Electroporation mediated injection
- Needless injection
Clinical Results
Over 1300 trials registered to date (source John Wiley, Journal of Gene Medicine) within the following indications: cancer 66.5%, cardiovascular 9.1%, monogenic diseases 8.3%, infectious disease 6.5%, others 9.6%.
Trials listed on the US NIH website or
Trials listed on the IFPMA website.
Eurogentec and DNA Vaccines
- We can produce your DNA plasmid in a non-antibiotic environment - highly recommended by the FDA and the EMEA
- Equipped to produce pre-clinical, clinical and commercial amounts
- cGMP manufacturing conditions
- Complete transfer, development, scale up, and manufacturing services
- Master Cell bank and Working Cell bank production
- Stability testing
- To learn more just contact us with your project goals.