Amyloid Precursor Protein
Amyloid precursor protein (APP) is a trans-membrane glycoprotein expressed in many tissues and concentrated in the synapses of neurons. APP processing ...
Aph-1
The gamma secretase is a multiprotein complex consisting of presenilin, nicastrin, Aph-1 and Pen-2; all four proteins are necessary for full proteolytic ...
Apolipoprotein E
The Apolipoprotein E4 allele is found in about 40% of patients with late onset Alzheimer's disease and as such, is considered as a risk factor. ...
Beta-secretase (BACE)
Processing of the β-amyloid precursor protein (APP) by β- and γ-secretases generates the β-amyloid peptides, whose accumulation in ...
Beta Amyloid
Beta-Amyloid (Aß) peptides are insoluble fibers which accumulate as plaques in the cerebral cortex of Alzheimer’s disease patients. A&beta ...
Blood-Brain Barrier
SMI 71 is specific for an endothelial protein found in areas with blood-brain or blood-nerve barriers. The antibody does not react with endothelia of periventricular ...
DJ-1
DJ-1 is a multifunctional protein associated with prostate cancer, male infertility, and oxidative stress. DJ-1 mutations have recently been shown as causative ...
Dopamine Decarboxylase
Aromatic L-amino acid decarboxylase (AADC; DOPA decarboxylase; DDC) catalyzes the second reaction in the biosynthesis of catecholamines and serotonin. ...
Dopamine Hydroxylase
Dopamine β-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine and serves as a marker of noradrenergic cells. The expression ...
Dopamine Transporter
Plasmalemmal neurotransmitter transporters sequester synaptic and peri-synaptic transmitter into presynaptic elements. The Dopamine Transporter (DAT) is ...
Enolase, neuron specific
Neuron specific enolase is found in elevated concentrations in plasma and certain neoplasias. These include pediatric neuroblastoma and small cell lung ...
ERAB
ERAB, also known as HSD-10 and ABAD, has been associated with amyloid beta neurotoxicity. ERAB is an intracellular 27kDa polypeptide which appears to be ...
GABA Receptors
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through ...
Glial Fibrillary Acidic Protein (GFAP)
Glial Fibrillary Acidic Protein (GFAP) is a major fibrous protein of multiple sclerosis plaques. It was subsequently found to be a member of the 10nm or ...
Glutamate Receptor
The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They ...
Glycine Receptor
Glycine is an important inhibitory transmitter in the brainstem and spinal cord. Glycine receptors are members of the ligand-gated ion channel family ...
Huntingtin-Interacting Protein 1 (HIP-1)
Huntingtin-interacting protein 1 (HIP-1) is a 116 kDa cofactor in clathrin-mediated endocytosis. Clone 4B10 was raised against human HIP-1 (GST fusion ...
Insulin Degrading Enzyme (IDE)
Insulin degrading enzyme (IDE), also known as insulinase, insulin protease or insulysin, cleaves the peptide hormone insulin with consequences for insulin ...
L1 NCAM
The cell adhesion molecule L1 is a 200-220 kDa protein of the immunoglobulin superfamily. It participates in a wide variety of neuronal functions including ...
Microtubule Associated Proteins (MAPs)
Microtubules are required for many well characterized functions in eukaryotic cells, including the movement of chromosomes in mitosis and meiosis, intracellular ...
Myelin Basic Protein
Myelin Basic Protein (MBP) is present in the central and peripheral nervous system, and is involved in the process of myelination of nerves. ...
Myelin CNPase
Myelin CNPase (2',3'-cyclic nucleotide 3'- phosphodiesterase) is a dimeric myelin-associated enzyme present in the central and peripheral nervous systems ...
Nestin
Nestin, a class IV intermediate filament protein is expressed during early stages of development in the CNS and in myogenic tissues. Upon differentiation ...
Neurofilaments
Neurofilaments are type IV intermediate filaments found in neurons. They consist of three protein subunits termed NF-H (200 kDa), NF-M (160 kDa) and NF ...
Neuronal Tubulin
Neuronal tubulin is the most abundant brain protein. Antibodies specific to Neuronal Class III β-tubulin (βIII) specifically stain neurons but ...
Nicotinic Acetylcholine Receptor, neuronal
Neuronal nicotinic acetylcholine receptors (nAChRs) are cholinergic receptors present in the central and peripheral nervous system. They play key roles ...
Nicastrin
The gamma secretase is a multiprotein complex consisting of presenilin, nicastrin, Aph-1 and Pen-2; all four proteins are necessary for full proteolytic ...
NMDA Receptors
Glutamate activated Ion channels that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDA receptor plays an essential ...
Notch
The Notch pathway is a highly conserved signaling pathway involved in key cellular functions such as proliferation, differentiation, stem cell maintenance ...
p75 Neurotrophin Receptor
The p75 Neurotrophin Receptor plays a pivotal role in the regulation of life and death decisions within developing neurons. ...
Paired Helical Filaments
Paired helical filaments are the core constituents of the neurofibrillary tangles of Alzheimer's disease and occur in other brain diseases like Down syndrome ...
Parkin
Parkinson’s disease is characterized by a decline of neurons in the so-called Substantia Nigra, a structure in the midbrain that produces dopamine ...
PEN-2
The gamma secretase is a multiprotein complex consisting of presenilin, nicastrin, Aph-1 and Pen-2; all four proteins are necessary for full proteolytic ...
Peripherin
Peripherin is a ~57kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems. Subsequently peripherin was ...
PP2A Inhibitors
A decreased activity of protein phosphatase-2A (PP2A) is believed to be associated to the abnormal hyperphosphorylation of Tau in Alzheimer's disease. ...
Presenilin
The gamma secretase is a multiprotein complex consisting of presenilin, nicastrin, Aph-1 and Pen-2; all four proteins are necessary for full proteolytic ...
Prion
Prion proteins (Prp-sc) are abnormal, transmissible proteic agents able to induce abnormal folding of normal cellular prion proteins (Prp-c) in the brain ...
Serotonin
Serotonin or 5-hydroxytryptamine (5-HT) is a neurotransmitter derived from tryptophan. It is mainly found in the gastrointestinal tract, platelets, and ...
SNAP-25
SNAP-25 (Synaptosomal-Associated Protein-25) is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. ...
Synapsin
Synapsins are neuron-specific phosphoproteins that localize to the cytoplasmic face of small synaptic vesicles, with little or no expression in other tissues ...
Synaptic Protein
SMI 82 reacts with unidentified synaptic and neuronal components. On Western blots of developing rat brain the antibody reacts with several bands, the ...
Synaptobrevin
Synaptobrevins are small membrane proteins of synaptic vesicles, which are secretory organelles of neurons that actively accumulate neurotransmitters and ...
Synaptophysin
Synaptophysin is a synaptic vesicle glycoprotein participating in synaptic transmission ...
Syntaxin
Syntaxins are membrane proteins which bind to synaptobrevin and SNAP-25 to form the core SNARE complex. ...
Synuclein
Synucleins are small soluble proteins expressed primarily in neural tissues and in certain tumors. The family includes 3 known proteins, alpha synuclein ...
Tau
Tau are microtubule-associated proteins that is involved in microtubule assembly and stabilization. In adult human brain, 6 isoforms are produced by alternative ...
Tryptophan Hydroxylase
Tryptophan hydroxylase (TPH) catalyzes the first step in the biosynthesis of serotonin and melatonin. In mammals, serotonin biosynthesis occurs predominantly ...
Tyrosine Hydroxylase
Tyrosine Hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines Dopamine and Norepinephrine. TH antibodies can therefore be ...
Voltage Gated Potassium Channel
Voltage-gated K+ channels are important determinants of neuronal membrane excitability, and differences in K+ channel expression patterns and densities ...
Amyloid Precursor Protein
Amyloid precursor protein (APP) is a trans-membrane glycoprotein expressed in many tissues and concentrated in the synapses of neurons. APP processing ...
Aph-1
The gamma secretase is a multiprotein complex consisting of presenilin, nicastrin, Aph-1 and Pen-2; all four proteins are necessary for full proteolytic ...
Apolipoprotein E
The Apolipoprotein E4 allele is found in about 40% of patients with late onset Alzheimer's disease and as such, is considered as a risk factor. ...
Beta-secretase (BACE)
Processing of the β-amyloid precursor protein (APP) by β- and γ-secretases generates the β-amyloid peptides, whose accumulation in ...
Beta Amyloid
Beta-Amyloid (Aß) peptides are insoluble fibers which accumulate as plaques in the cerebral cortex of Alzheimer’s disease patients. A&beta ...
Blood-Brain Barrier
SMI 71 is specific for an endothelial protein found in areas with blood-brain or blood-nerve barriers. The antibody does not react with endothelia of periventricular ...
DJ-1
DJ-1 is a multifunctional protein associated with prostate cancer, male infertility, and oxidative stress. DJ-1 mutations have recently been shown as causative ...
Dopamine Decarboxylase
Aromatic L-amino acid decarboxylase (AADC; DOPA decarboxylase; DDC) catalyzes the second reaction in the biosynthesis of catecholamines and serotonin. ...
Dopamine Hydroxylase
Dopamine β-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine and serves as a marker of noradrenergic cells. The expression ...
Dopamine Transporter
Plasmalemmal neurotransmitter transporters sequester synaptic and peri-synaptic transmitter into presynaptic elements. The Dopamine Transporter (DAT) is ...
Enolase, neuron specific
Neuron specific enolase is found in elevated concentrations in plasma and certain neoplasias. These include pediatric neuroblastoma and small cell lung ...
ERAB
ERAB, also known as HSD-10 and ABAD, has been associated with amyloid beta neurotoxicity. ERAB is an intracellular 27kDa polypeptide which appears to be ...
GABA Receptors
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through ...
Glial Fibrillary Acidic Protein (GFAP)
Glial Fibrillary Acidic Protein (GFAP) is a major fibrous protein of multiple sclerosis plaques. It was subsequently found to be a member of the 10nm or ...
Glutamate Receptor
The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They ...
Glycine Receptor
Glycine is an important inhibitory transmitter in the brainstem and spinal cord. Glycine receptors are members of the ligand-gated ion channel family ...
Huntingtin-Interacting Protein 1 (HIP-1)
Huntingtin-interacting protein 1 (HIP-1) is a 116 kDa cofactor in clathrin-mediated endocytosis. Clone 4B10 was raised against human HIP-1 (GST fusion ...
Insulin Degrading Enzyme (IDE)
Insulin degrading enzyme (IDE), also known as insulinase, insulin protease or insulysin, cleaves the peptide hormone insulin with consequences for insulin ...
L1 NCAM
The cell adhesion molecule L1 is a 200-220 kDa protein of the immunoglobulin superfamily. It participates in a wide variety of neuronal functions including ...
Microtubule Associated Proteins (MAPs)
Microtubules are required for many well characterized functions in eukaryotic cells, including the movement of chromosomes in mitosis and meiosis, intracellular ...
Myelin Basic Protein
Myelin Basic Protein (MBP) is present in the central and peripheral nervous system, and is involved in the process of myelination of nerves. ...
Myelin CNPase
Myelin CNPase (2',3'-cyclic nucleotide 3'- phosphodiesterase) is a dimeric myelin-associated enzyme present in the central and peripheral nervous systems ...
Nestin
Nestin, a class IV intermediate filament protein is expressed during early stages of development in the CNS and in myogenic tissues. Upon differentiation ...
Neurofilaments
Neurofilaments are type IV intermediate filaments found in neurons. They consist of three protein subunits termed NF-H (200 kDa), NF-M (160 kDa) and NF ...
Neuronal Tubulin
Neuronal tubulin is the most abundant brain protein. Antibodies specific to Neuronal Class III β-tubulin (βIII) specifically stain neurons but ...
Nicotinic Acetylcholine Receptor, neuronal
Neuronal nicotinic acetylcholine receptors (nAChRs) are cholinergic receptors present in the central and peripheral nervous system. They play key roles ...
Nicastrin
The gamma secretase is a multiprotein complex consisting of presenilin, nicastrin, Aph-1 and Pen-2; all four proteins are necessary for full proteolytic ...
NMDA Receptors
Glutamate activated Ion channels that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDA receptor plays an essential ...
Notch
The Notch pathway is a highly conserved signaling pathway involved in key cellular functions such as proliferation, differentiation, stem cell maintenance ...
p75 Neurotrophin Receptor
The p75 Neurotrophin Receptor plays a pivotal role in the regulation of life and death decisions within developing neurons. ...
Paired Helical Filaments
Paired helical filaments are the core constituents of the neurofibrillary tangles of Alzheimer's disease and occur in other brain diseases like Down syndrome ...
Parkin
Parkinson’s disease is characterized by a decline of neurons in the so-called Substantia Nigra, a structure in the midbrain that produces dopamine ...
PEN-2
The gamma secretase is a multiprotein complex consisting of presenilin, nicastrin, Aph-1 and Pen-2; all four proteins are necessary for full proteolytic ...
Peripherin
Peripherin is a ~57kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems. Subsequently peripherin was ...
PP2A Inhibitors
A decreased activity of protein phosphatase-2A (PP2A) is believed to be associated to the abnormal hyperphosphorylation of Tau in Alzheimer's disease. ...
Presenilin
The gamma secretase is a multiprotein complex consisting of presenilin, nicastrin, Aph-1 and Pen-2; all four proteins are necessary for full proteolytic ...
Prion
Prion proteins (Prp-sc) are abnormal, transmissible proteic agents able to induce abnormal folding of normal cellular prion proteins (Prp-c) in the brain ...
Serotonin
Serotonin or 5-hydroxytryptamine (5-HT) is a neurotransmitter derived from tryptophan. It is mainly found in the gastrointestinal tract, platelets, and ...
SNAP-25
SNAP-25 (Synaptosomal-Associated Protein-25) is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. ...
Synapsin
Synapsins are neuron-specific phosphoproteins that localize to the cytoplasmic face of small synaptic vesicles, with little or no expression in other tissues ...
Synaptic Protein
SMI 82 reacts with unidentified synaptic and neuronal components. On Western blots of developing rat brain the antibody reacts with several bands, the ...
Synaptobrevin
Synaptobrevins are small membrane proteins of synaptic vesicles, which are secretory organelles of neurons that actively accumulate neurotransmitters and ...
Synaptophysin
Synaptophysin is a synaptic vesicle glycoprotein participating in synaptic transmission ...
Syntaxin
Syntaxins are membrane proteins which bind to synaptobrevin and SNAP-25 to form the core SNARE complex. ...
Synuclein
Synucleins are small soluble proteins expressed primarily in neural tissues and in certain tumors. The family includes 3 known proteins, alpha synuclein ...
Tau
Tau are microtubule-associated proteins that is involved in microtubule assembly and stabilization. In adult human brain, 6 isoforms are produced by alternative ...
Tryptophan Hydroxylase
Tryptophan hydroxylase (TPH) catalyzes the first step in the biosynthesis of serotonin and melatonin. In mammals, serotonin biosynthesis occurs predominantly ...
Tyrosine Hydroxylase
Tyrosine Hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines Dopamine and Norepinephrine. TH antibodies can therefore be ...
Voltage Gated Potassium Channel
Voltage-gated K+ channels are important determinants of neuronal membrane excitability, and differences in K+ channel expression patterns and densities ...
