Peptides

ß-Amyloid (1-42), HiLexa Fluor™ 488-labeled - 0.1 mg

231.00
Check your price
  • Cat.Number : AS-65627
  • Availability :
    In stock

Select specification

Quantity

Aß (1-42), a major component of amyloid plaques, accumulates in neurons of Alzheimer’s disease brains. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Aß (1-42) is the principal species associated with senile plaque amyloids, while Aß (1-40) is more abundant in cerebrovascular amyloid deposit.


This is a fluorescent (HiLexa™ Fluor 488) labeled ß-Amyloid peptide, Abs/Em=503/528 nm. HiLexa 488™ Fluor labeled Aß (1-42) offers brighter intensity with high fluorescence quantum yield and photostability suitable for pH-insensitive applications including flow cytometry and imaging. HiLexa™ Fluor 488 is the same structure as that of Alexa® Fluor 488.

HiLexa™ Fluor 488 labeled ß-Amyloid peptide can be used in studies applicable for monitoring aggregation kinetics of Aβ via steady-state fluorescence, measuring amyloid aggregates in cellular compartments in live neurons via confocal microscopy, quantification of Aβ(1-42) by flow cytometry upon cellular uptake, monitoring Aβ fibrillogenesis via fluorescence correlation spectroscopy, assaying Aβ degradation, evaluating role of autophagy in cell lines via immunoblotting, in vitro phagocytosis assay to determine uptake efficacy by macrophages, and a host of other applications including immunocytochemistry, RT-PCR etc.

Specifications

Chemistry
Sequence one letter code
  • HiLexa™ Fluor 488-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Sequence three letter code
  • HiLexa™ Fluor 488-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
Molecular Mass/ Weight
  • 5030.8
Properties
Absorbance (nm)
  • 503
Emission (nm)
  • 528
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Codes
Code Nacres
  • NA.26

You may also be interested in the following product(s)

Tube of 1percent NH4OH solution 300 µl peptide

1 % NH4OH solution - 300 µl

Cat.Number : AS-61322
20.00 Excl. Tax
Image of a kit SensoLyte 520 Neprilysin Activity Assay Kit Fluorimetric

SensoLyte® 520 Neprilysin Activity Assay Kit Fluorimetric - 1 kit

Cat.Number : AS-72223
509.00 Excl. Tax
Image of a kit SensoLyte Thioflavin T Beta-Amyloid (1-42) Aggregation Kit

SensoLyte® Thioflavin T ß-Amyloid (1-42) Aggregation Kit - 1 kit

Cat.Number : AS-72214
509.00 Excl. Tax