2' O-MOE RNA Base Phosphorothioate Linkage - 1 base with PTO Linkage

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  • Cat.Number : BA-ME010-004
  • Availability :
    In production

Synthesis scale

Alternative choices

2’-O-(2-Methoxyethyl)- oligoribonucleotides or 2’-O-MOE have an analogue chemical structure to RNA excepted that a methoxy-ethyl residue is attached at the 2’-O-position.
The chemical group at this position confers to the oligo backbone a highest nuclease resistance and a better binding affinity compared to the classical RNA molecule making it a useful tool for antisens applications.
At Eurogentec we use 2’ -MOE-A, 2’ -MOE-5Me-C, 2’ -MOE-G and 2’ -MOE-5-Me-U as 2’O-MOE bases.
- Nuclease resistant
- High binding affinity
- Reduced unspecific protein binding
- Superior half life in tissues
Phosphorothioate bonds possess an increased resistance against nucleases due to the substitution of a non-bridging oxygen by sulphur.

Length: From 5 to 139 bases
Synthesis scale: 40 nmol - 200 nmol - 1000nmol - 2.5 µmol - 5µmol - 10 µmol - 20 µmol (Larger quantities available on request)
Modifications: More than 300 modifications available
Purifications: SePOP desalting, HPLC, PAGE, Dual HPLC
Quality Control: MALDI-TOF MS
Format: Dried. other formats on option
Packaging: 2 mL tube, 96-well or 384-well plates. Higher scales from 2.5 µmol may be delivered in 50mL tubes.


  • Phosphorothioate Linkage
Molecular Mass/ Weight
  • -
Modification Position
  • 3'
  • 5'
  • IN
Storage & stability
Resuspension condition
  • - Spin the tube briefly to collect the pellet in the bottom of the tube - Add an appropriate volume of recommended buffer (refer to technical data sheet) - Allow the tube to stand a few minutes - Vortex the tube for 15 seconds
Storage Conditions
  • Dried Oligonucleotides are stable for 18 months at ambiant temperature. Oligonucleotides in solutions are stable for 24 months at -20°C. (Tolerance -20°C± 5°C. ) For more information please refer to the Reconstitution-Storage-Stability page
  • Research use
Code Nacres
  • NA.51

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