Oligos

2' O-MOE RNA Base Phosphorothioate Linkage - 1 base with PTO Linkage

11,50
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  • Cat.Number : BA-ME010-004
  • Availability :
    In production

Select specification

Synthesis scale

2’-O-(2-Methoxyethyl)- oligoribonucleotides or 2’-O-MOE have an analogue chemical structure to RNA excepted that a methoxy-ethyl residue is attached at the 2’-O-position.
The chemical group at this position confers to the oligo backbone a highest nuclease resistance and a better binding affinity compared to the classical RNA molecule making it a useful tool for antisens applications.
Benefits
- Nuclease resistant
- High binding affinity
- Reduced unspecific protein binding
- Superior half life in tissues

Phosphorothioate bonds possess an increased resistance against nucleases due to the substitution of a non-bridging oxygen by sulphur.


Length: From 5 to 139 bases
Synthesis scale: 10 nmol - 40 nmol - 200 nmol - 1000nmol - 2.5 µmol - 5µmol - 10 µmol (Larger quantities available on request)
Modifications: More than 300 modifications available
Purifications: SePOP desalting, HPLC, PAGE, Dual HPLC, UltraPureGold™
Quality Control: MALDI-TOF MS
Format: Dried. other formats on option
Packaging: 2 mL tube, 96-well or 384-well plates

Specifications

Chemistry
Linkage
  • Phosphorothioate Linkage
Molecular Mass/ Weight
  • -
Modification
Modification Position
  • IN
  • 5'
  • 3'
Storage & stability
Resuspension condition
  • - Spin the tube briefly to collect the pellet in the bottom of the tube - Add an appropriate volume of recommended buffer (refer to technical data sheet) - Allow the tube to stand a few minutes - Vortex the tube for 15 seconds
Storage Conditions
  • Dried Oligonucleotides are stable for 18 months at ambiant temperature. Oligonucleotides in solutions are stable for 24 months at -20°C. (Tolerance -20°C± 5°C. ) For more information please refer to the Reconstitution-Storage-Stability page
Activity
Usage
  • Research use

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