Tube of Beta-Amyloid (1-42) peptide, HL555-labeled
Peptides

Beta-Amyloid (1-42), HiLyte™ Fluor 555-labeled - 0.1 mg

€296.00
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  • Cat.Number : AS-60480-01
  • Availability :
    In production

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Aß (1-42), a major component of amyloid plaques, accumulates in neurons of Alzheimer’s disease brains. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Aß (1-42) is the principal species associated with senile plaque amyloids, while Aß (1-40) is more abundant in cerebrovascular amyloid deposit. This is a fluorescent (HiLyte™ Fluor 555)-labeled ß-Amyloid peptide, Abs/Em=551/567 nm.

Specifications

Chemistry
Sequence one letter code
  • HiLyte Fluor™ 555-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Sequence three letter code
  • HiLyte™ Fluor 555-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
Molecular Mass/ Weight
  • 5366.6
Properties
Absorbance (nm)
  • 551
Emission (nm)
  • 567
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human
Codes
Code Nacres
  • NA.26

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Citations

Reduction of Synaptojanin 1 Accelerates Aβ Clearance and Attenuates Cognitive Deterioration in an Alzheimer Mouse Model

J Biol Chem. . 2013 Nov 01 ; 288(44) 32050 | DOI : 10.1074/jbc.M113.504365

  • L. Zhu
  • et al

Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1

Nature . 2018 Sep 24 ; 8 14267 | DOI : 10.1038/s41598-018-32572-2

  • MM. Maneshi
  • et al

Microglia constitute a barrier that prevents neurotoxic protofibrillar ​Aβ42 hotspots around plaques

Nat Commun. . 2015 Jan 29 ; 6 6176 | DOI : 10.1038/ncomms7176

  • C. Condello
  • et al

Acute amnestic encephalopathy in amyloid-ß oligomers injected mice is due to their widespread diffusion in vivo

Neuro Aging . 2015 Jun 01 ; 36(6) 2043 | DOI : https://doi.org/10.1016/j.neurobiolaging.2015.03.005

  • S. Epelbaum
  • et al

Amyloid β peptide stimulates platelet activation through RhoA-dependent modulation of actomyosin organization

FASEB J . 2014 Jan 13 ; 28(4) 1819 | DOI : https://doi.org/10.1096/fj.13-243691

  • VK. Sonkar
  • et al

Real-time probing of β-amyloid self-assembly and inhibition using fluorescence self-quenching between neighbouring dyes

Mol Biosyst.  . 2013 Oct 29 ; 10(1) 34 | DOI : 10.1039/c3mb70272c

  • SD. Quinn
  • et al

Size-dependent neurotoxicity of β-amyloid oligomers

Arch Biochem Biophys . 2010 Apr 15 ; 496(2) 84 | DOI : 10.1016/j.abb.2010.02.001

  • P. Cizas
  • et al

CX3CR1 in Microglia Regulates Brain Amyloid Deposition through Selective Protofibrillar Amyloid-β Phagocytosis

J Neurosci. . 2012 Dec 15 ; 30(50) 17091 | DOI : 10.1523/JNEUROSCI.4403-10.2010

  • Z. Liu
  • et al

Ca2+ Regulation of Dynamin-Independent Endocytosis in Cortical Astrocytes

J Neurosci. . 2009 Jun 24 ; 29(25) 8063 | DOI : 10.1523/JNEUROSCI.6139-08.2009

  • M. Jiang
  • G. Chen

Direct Observations of Amyloid β Self-Assembly in Live Cells Provide Insights into Differences in the Kinetics of Aβ(1–40) and Aβ(1–42) Aggregation

Chem Biol. . 2014 Jun 19 ; 21(6) 732 | DOI : 10.1016/j.chembiol.2014.03.014

  • EK. Esbjörner
  • et al

Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage

Biochemistry. . 2014 Apr 09 ; 53(15) 2442 | DOI : 10.1021/bi401606f

  • P. Narayan
  • et al