Peptides

Beta-Amyloid (1-42), sodium salt

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  • Cat.Number : AS-60883-01
  • Availability :
    In stock

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Aß (1-42), a major component of amyloid plaques, accumulates in neurons of Alzheimer’s disease brains. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Aß (1-42) is the principal species associated with senile plaque amyloids, while Aß (1-40) is more abundant in cerebrovascular amyloid deposit. This peptide prepared by neutralizing the TFA salt form of Aß (1-42) with a diluted sodium hydroxide solution has superior solubility and fibrillogenesis properties, and the fibrils are equally neurotoxic.

Specifications

Chemistry
Sequence one letter code
  • DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Sequence three letter code
  • H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
CAS registry number
  • 107761-42-2
Molecular Formula
  • C203H311N55O60S
Molecular Mass/ Weight
  • 4514.1•23
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human
Codes
Code Nacres
  • NA.26

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Citations

A novel β-sheet breaker, RS-0406, reverses amyloid β-induced cytotoxicity and impairment of long-term potentiation in vitro.

Br J Pharmacol . 2002 Oct 16 ; 137(5) 676 | DOI : 10.1038/sj.bjp.0704911.

  • Y. Nakagami
  • et al

Synthesis and biological evaluation of novel N,N′-bis-methylenedioxybenzyl-alkylenediamines as bivalent anti-Alzheimer disease ligands.

J Enzyme Inhibition Med Chem . 2014 Jan 09 ; 26(5) 706 | DOI : 10.3109/14756366.2010.548329.

  • W. Luo
  • et al