Peptides

Beta-Amyloid (25-35)

48.00
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  • Cat.Number : AS-24227-
  • Availability :
    In stock

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Size

Quantity

Aß (25-35) is the main factor responsible for Aß neurotoxic effects.

Specifications

Chemistry
Sequence one letter code
  • GSNKGAIIGLM
Sequence three letter code
  • H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH
CAS registry number
  • 131602-53-4
Molecular Formula
  • C45H81N13O14S
Molecular Mass/ Weight
  • 1060.4
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human
Codes
Code Nacres
  • NA.26

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Citations

LC3 overexpression reduces Aβ neurotoxicity through increasing α7nAchR expression and autophagic activity in neurons and mice

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  • et al

S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by β-amyloid peptide

PNAS . 2011 Aug 23 ; 108(34) 14330 | DOI : https://doi.org/10.1073/pnas.1105172108

  • J. Qu
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CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia

Cellular Immuno . 2010 Jan 01 ; 260(2) 113 | DOI : https://doi.org/10.1016/j.cellimm.2009.10.001

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Effects of NK-4 in a Transgenic Mouse Model of Alzheimer's Disease

PLoS One. . 2012 Jan 04 ; 7(1) e30007 | DOI : https://doi.org/10.1371/journal.pone.0030007

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Dissociating β-amyloid from α7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes α7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain.

J Neurosci . 2009 Sep 02 ; 29(35) 10961 | DOI : 10.1523/JNEUROSCI.6088-08.2009

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Enlargement of Aβ aggregates through chemokine-dependent microglial clustering.

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Monocyte-mediated regulation of genes by the amyloid and prion peptides in SH-SY5Y neuroblastoma cells.

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Identification of small molecule inhibitors of β-amyloid cytotoxicity through a cell-based high-throughput screening platform.

J Biomol Screen . 2008 Sep 23 ; 13(9) 870 | DOI : 10.1177/1087057108323909

  • K. Seyb
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Novel Genetic Tools Reveal Cdk5’s Major Role in Golgi Fragmentation in Alzheimer’s Disease.

Mol Biol Cell . 2008 May 15 ; 19(7) 3052 | DOI : 10.1091/mbc.e07-11-1106

  • K. Sun
  • et al

Neuroprotective effects of Yi-Gan San against beta amyloid-induced cytotoxicity on rat cortical neurons.

Pro Neuro-Pyschopharmacol Biol Pysch . 2008 Oct 01 ; 32(7) 1704 | DOI : 10.1016/j.pnpbp.2008.07.006

  • M. Tateno
  • et al

Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid β and interferon-γ-induced microglial activation.

Free Radic Biol Med . 2006 Dec 09 ; 42(7) 945 | DOI : 10.1016/j.freeradbiomed.2006.12.003

  • S. Hashioka
  • et al

Gene expression profile in β-amyloid-treated SH-SY5Y neuroblastoma cells.

Brain Res Bull . 2007 Feb 07 ; 72(4-6) 225 | DOI : 10.1016/j.brainresbull.2007.01.010

  • T. Martínez
  • A. Pascual

Differential effects of buckwheat and kudingcha extract on neuronal damage in cultured hippocampal neurons and spatial memory impairment induced by scopolamine in an eight-arm radial maze.

J Health Sci . 2005 Aug 29 ; 51(6) 363 | DOI : 10.1248/jhs.51.636

  • F. Pu
  • et al

Hypoxia enhances β-amyloid-induced apoptosis in rat cultured hippocampal neurons.

Jpn J Pharmacol. . 2002 Dec 01 ; 90(4) 321 | DOI : 10.1254/jjp.90.321

  • N. Egashira
  • et al

Alzheimer's amyloid β-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: protective effect of vitamin E.

Neurosci Lett . 1999 Mar 19 ; 263(1) 17 | DOI : 10.1016/s0304-3940(99)00101-9

  • S. Yatin
  • et al

Temporal relations among amyloid β-peptide-induced free-radical oxidative stress, neuronal toxicity, and neuronal defensive responses.

J Mol Neurosci. . 1998 Dec 01 ; 11(3) 183 | DOI : 10.1385/JMN:11:3:183

  • SM. Yatin
  • et al