Peptides

Cys(Npys)-(Arg)9 - 1 mg

240.00
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  • Cat.Number : AS-61205
  • Availability :
    In stock

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This is a peptide comprising of 9 Arginine residues and is synthesized with an activated cysteine residue C(Npys), wherein Npys is 3-Nitro-2-pyridinesulfenyl group protects cysteine. This kind of modification has been used to render this peptide as a carrier peptide applicable in conjugation and cell permable studies. The S(Npys) group of this cysteine-containing 9R is capable of reacting selectively with the free thiol group of another cysteine-containing peptide to form an unsymmetrical disulfide bond. Coupling of sulfhydrils has been studied as an effective means to deliver/release therapeutics such as siRNA in the reducing environment within the cell. For example, in a study leukemic-specific SiRNA was delivered by the formation of immunocomplexes that consisted of targeted antibody conjugated to oligo-9-Arg peptides.

Specifications

Chemistry
Sequence one letter code
  • C(Npys)RRRRRRRRR-NH2
Sequence three letter code
  • H-Cys(Nyps)-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-NH2
CAS registry number
  • 1417221-06-7
Molecular Formula
  • C62H118N40O12S2
Molecular Mass/ Weight
  • 1680
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Synthetic construct
Codes
Code Nacres
  • NA.26

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