Peptides

[D-Tyr6, ß-Ala11, Phe13, Nle14]-Bombesin (6-14) - 1 mg

132,00
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  • Cat.Number : AS-60134-1
  • Availability :
    In stock

Quantity

This peptide is a universal Bombesin synthetic ligand, binding to all 3 bombesin receptors.
Bombesin is a 14-aa peptide originally isolated from the fire-bellied toad. It has two mammalian homologs, neuromedin and Gastrin-Releasing Peptide (GRP). It binds with high affinity to the GRP receptor, a member of the G-protein-coupled receptor family. It stimulates gastrin release from G cells, and acts in the brain to stop eating behavior. Bombesin is also a tumor marker for lung small cell carcinoma, neuroblastoma, pancreatic cancer and gastric cancer.

Specifications

Chemistry
Sequence one letter code
  • yQWAV-(ß-A)-HF-Nle-NH2
Sequence three letter code
  • H-D-Tyr-Gln-Trp-Ala-Val-ß-Ala-His-Phe-Nle-NH2
Molecular Formula
  • C57H76N14O11
Molecular Mass/ Weight
  • 1133.3
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • toad

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Citations

Effect of bombesin receptor subtype-3 and its synthetic agonist on signaling, glucose transport and metabolism in myocytes from patients with obesity and type 2 diabetes.

Intl J Mol Med . 2015 Feb 04 ; 35(4) 925 | DOI : 10.3892/ijmm.2015.2090

  • N. González
  • et al