Peptides

epsilon-V1-2, PKCe Inhibitor - 1 mg

71.00
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  • Cat.Number : AS-62186
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    In stock

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This peptide is derived from residues 14-21 of protein kinase C C2 (εPKC C2). This peptide specifically inhibits εPKC by disrupting PKC binding to its receptor, RACK2. εPKC mediated signal transduction plays a role in cell proliferation, differentiation, and apoptosis.

Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.

Specifications

Chemistry
Sequence one letter code
  • EAVSLKPT
Sequence three letter code
  • H-Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr-OH
Molecular Formula
  • C37H65N9O13
Molecular Mass/ Weight
  • 844
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Application
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Human, mouse, rat, bovine
Codes
Code Nacres
  • NA.26

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Citations

Sigma-1 receptor-induced increase in murine spinal NR1 phosphorylation is mediated by the PKCα and var epsilon, but not the PKCζ, isoforms

Neurosci Lett. . 2010 Apr 22 ; 477(2) 95 | DOI : 10.1016/j.neulet.2010.04.041

  • D. Roh
  • et al