Peptides

Gap 26, Connexin 43 (63-75) (human, mouse, rat, bovine) - 1 mg

77,00
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  • Cat.Number : AS-62644
  • Availability :
    In stock

Quantity

This Gap 26 peptide is derived from the first extracellular loop sequence of connexin (Cx) 43. This short mimetic peptide reversibly inhibits the gap junction-dependent propagation of Ca2+ waves between tracheal airway epithelial cells. Connexins, or gap junctions, are a family of structurally-related transmembrane proteins. Gap junctions contain channels that allow the passage of ions and small molecules between adjacent cells molecules. Calcium and inositol phosphates are among the second messengers that can pass through gap junction channels.

Specifications

Chemistry
Sequence one letter code
  • VCYDKSFPISHVR
Sequence three letter code
  • H-Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg-OH
CAS registry number
  • 197250-15-0
Molecular Formula
  • C70H107N19O19S
Molecular Mass/ Weight
  • 1550.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Human, mouse, rat, bovine

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Citations

Neuroinflammation Leads to Region-Dependent Alterations in Astrocyte Gap Junction Communication and Hemichannel Activity.

J Neurosci . 2011 Jan 12 ; 31(2) 414 | DOI : 10.1523/JNEUROSCI.5247-10.2011

  • N. Karpuk
  • et al