Peptides

Ghrelin, rat, mouse Peptide

911,00
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  • Cat.Number : AS-24160
  • Availability :
    In stock

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Rat/mouse Ghrelin differs from human Ghrelin on the 11th and 12th position - RV (Arg-Val) in rat/mouse and KA (Lys-Ala) in human. Ghrelin is an appetite stimulating peptide hormone secreted by stomach P/D1-type cells in humans and circulates in the bloodstream during fasting conditions. Enzymatically n-octanoylated Serine3 of this 28-amino acid Ghrelin is the endogenous ligand specific for growth hormone secretagogue receptor 1a (GHSR1a). The GHSR1a receptor appears to be dedicated to Ghrelin and is widely expressed in different tissues.

Specifications

Chemistry
Sequence one letter code
  • GS-S(n-octanoyl)-FLSPEHQKAQQRKESKKPPAKLQPR
Sequence three letter code
  • H-Gly-Ser-[Ser(n-octanoyl)]-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH
CAS registry number
  • 258338-12-4
Molecular Formula
  • C147H245N45O42
Molecular Mass/ Weight
  • 3314.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • rat

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Citations

The effects of ghrelin on ovary histology in Barbus sharpeyi.

J Anim Physiol Anim Nutr . 2011 Jan 28 ; 95(5) 599 | DOI : 10.1111/j.1439-0396.2010.01089.x.

  • H. Mabudi
  • et al

Effects of different feeding programs and ghrelin injection on plasma ghrelin concentrations and distribution of the ghrelin positive cells in the abomasum of Awassi male lambs.

Revue Méd. Vét. . 2011 Jan 01 ; 162(2) 65

  • N. Ozfiliz
  • et al

Effects of repeated administered ghre3lin on chronic constriction injury of the sciatic nerve in rats.

Neurosci Lett . 2010 Jun 01 ; 479(3) 226 | DOI : 10.1016/j.neulet.2010.05.066

  • E. Guneli
  • et al

Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats.

Neurosci Lett . 2009 Jan 30 ; 453(1) 58 | DOI : 10.1016/j.neulet.2009.01.067

  • J. Xu
  • et al

Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways.

Surgery . 2007 Dec 27 ; 43(3) 334 | DOI : 10.1016/j.surg.2007.09.039

  • T. Waseem
  • et al

Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone.

Cell . 2008 Feb 08 ; 132(3) 387 | DOI : 10.1016/j.cell.2008.01.017

  • J. Yang
  • et al

Ghrelin enhances in vivo skeletal muscle but not liver AKT signaling in rats.

Obesity . 2007 Nov 01 ; 15(11) 261 | DOI : 10.1038/oby.2007.313

  • R. Barazzoni
  • et al

Ghrelin reduces injury of hippocampal neurons in a rat model of cerebral ischemia/reperfusion.

Chin J Physiol . 2006 Oct 31 ; 49(5) 244 | DOI : PMID: 17294832

  • Y. Liu
  • et al

Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle.

AJP-Endo Metab . 2004 Aug 24 ; 288(1) E228 | DOI : 10.1152/ajpendo.00115.2004

  • R. Barazzoni
  • et al