Peptides

GRGDS - 5 mg

56,00
Check your price
  • Cat.Number : AS-61107
  • Availability :
    In stock

Quantity

GRGDS is the cell adhesion sequence of osteopontin that recognizes the avb3 integrin. Osteopontin is overexpressed in experimental models of malignancy. Although the native form of OPN is active in cell attachment assays, it has been observed that thrombin cleavage of OPN causes substantial enhancement of it's attachment properties. This cleavage occurs within residues of the GRGDS sequence raising the possibility of thrombin-cleavage further activating OPN by allowing greater accessibility of the GRGDS domain to cell surface receptors. GRGDS synthetic peptide also mimics the cellular binding site of many adhesive proteins in the extracellular matrix and causes rounding and detachment of spread cells. It induces dissociation of alpha-actinin and vinculin from the sites of focal contacts.

Specifications

Chemistry
Sequence one letter code
  • GRGDS
Sequence three letter code
  • H-Gly-Arg-Gly-Asp-Ser-OH
CAS registry number
  • 96426-21-0
Molecular Formula
  • C17H30N8O9
Molecular Mass/ Weight
  • 490.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • synthetic

You may also be interested in the following product(s)

Tube of Laminin Pentapeptide

Laminin Pentapeptide - 5 mg

Cat.Number : AS-20806
66,00