Peptides

HCV NS3/4A Protease Substrate - 1 mg

670,00
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  • Cat.Number : AS-60798
  • Availability :
    In stock

Quantity

A highly sensitive FRET substrate for assaying HCV (Hepatitis C Virus) NS3/4A protease activity. It detects < 0.1pmol of HCV NS3/4A protease. Upon cleavage of this substrate, fluorescence can be monitored at Abs/Em = 490/512 nm.

Specifications

Chemistry
Sequence one letter code
  • Ac-DE-Dap(QXL520)-EE-Abu-?;-[COO]AS-C(5-FAMsp)-NH2
Sequence three letter code
  • Ac-Asp-Glu-Dap(QXL®520)-Glu-Glu-Abu-?-[COO]-Ala -Ser-Cys(5-FAMsp)-NH2
Molecular Mass/ Weight
  • 1913.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Application
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • HCV

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Citations

Identification of hepatitis C virus inhibitors targeting different aspects of infection using a cell-based assay.

Antimicrob Agents Chemother . 2012 Sep 04 ; 56(12) 6109 | DOI : 10.1128/AAC.01413-12

  • X. Yu
  • et al

Development of a cell-based hepatitis C virus (HCV) infection FRET assay for high throughput antiviral compound screening.

Antimicrob Agents Chemo . 2009 Jul 20 ; 53(10) 4311 | DOI : 10.1128/AAC.00495-09.

  • X. Yu
  • et al

Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227).

Antimicrob Agents Chemother . 2008 Sep 29 ; 52(12) 4432 | DOI : 10.1128/AAC.00699-08

  • S. Seiwert
  • et al

Biliverdin and Heme Oxygenase Antibiral Activity Against Hepatitis C Virus.

Ann Hepatol . 2011 Jan 01 ; 10(1) 105 | DOI : PMID: 21301021

  • Y. Gutierrez-Grobe
  • et al