Peptides

Human PD-L1 inhibitor I - 1 mg

143,00
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  • Cat.Number : AS-65581
  • Availability :
    In stock

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Programed cell death 1 (PD-1) receptor and its ligand PD-L1 are crucial immune checkpoints to downregulate T cell activation, tolerance and immunopathology. Several types of cancer cells were identified to overexpress PD-L1 so as to escape from the PD-1/PD-L1 immunosurveillance mechanism. This peptide, hPDL-1 inhibitor I binds to human PD-1 and inhibits PD-1/PD-L1 binding. It has anchor residues, WDY that show a great impact on the binding of hPD-L1 to hPD-1. Developing inhibitors specifically blocking the PD-1/PD-L1 pathway has become a popular approach to cancer treatment.

Specifications

Chemistry
Sequence one letter code
  • FNWDYSWKSERLKEAYDL
Sequence three letter code
  • H-Phe-Asn-Trp-Asp-Tyr-Ser-Trp-Lys-Ser-Glu-Arg-Leu-Lys-Glu-Ala-Tyr-Asp-Leu-OH
Molecular Formula
  • C110H152N26O32
Molecular Mass/ Weight
  • 2350.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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