Peptides

Human PD-L1 inhibitor IV - 1 mg

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  • Cat.Number : AS-65584
  • Availability :
    In stock

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Programed cell death 1 (PD-1) receptor and its ligand PD-L1 are crucial immune checkpoints to downregulate T cell activation, tolerance and immunopathology. Several types of cancer cells were identified to overexpress PD-L1 so as to escape from the PD-1/PD-L1 immunosurveillance mechanism. This peptide, hPDL-1 inhibitor IV binds to human PD-1 and inhibits PD-1/PD-L1 binding. It has anchor residues (underlined), GNWDYNSQRAQLYNQ that show a great impact on the binding of hPD-L1 to hPD-1. Developing inhibitors specifically blocking the PD-1/PD-L1 pathway became popular approach to cancer treatment.

Specifications

Chemistry
Sequence one letter code
  • GNWDYNSQRAQLYNQ
Sequence three letter code
  • H-Gly-Asn-Trp-Asp-Tyr-Asn-Ser-Gln-Arg-Ala-Gln-Leu-Tyr-Asn-Gln-OH
Molecular Formula
  • C80H113N25O27
Molecular Mass/ Weight
  • 1857
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human
Codes
Code Nacres
  • NA.26

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