LNA® (Locked Nucleic Acid) is a bicyclic nucleic acid with a structure locked into a rigid C3'-endo position, which favours RNA A-type helix duplex geometry.
This exceptional structure confers a very strong thermal stability towards complementary DNA and RNA template suitable for hybridization assays requiring high specificity and/or reproducibility.
Phosphorothioate bonds possess an increased resistance against nucleases due to the substitution of a non-bridging oxygen by sulphur.
Length: From 5 to 139 bases
Synthesis scale: 40 nmol - 200 nmol - 1000nmol - 2.5 µmol - 5µmol - 10 µmol - 20 µmol (Larger quantities on request)
Modifications: More than 300 modifications available
Purifications: SePOP desalting, RP-Cartridge-Gold™, HPLC, PAGE, Dual HPLC
Quality Control: MALDI-TOF MS
Format: Dried. other formats on option
Packaging: 2 mL tube, 96-well or 384-well plates. Higher scales from 2.5 µmol may be delivered in 50mL tubes.