Peptides

Melan-A, MART-1 (26-35) - 1 mg

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  • Cat.Number : AS-61011
  • Availability :
    In production

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This native Melan-A (26-35) decapeptide is an immunodominant antigen from melanocyte/melanoma (Melan-A/MART) protein that is more efficiently recognized by tumor-infiltrating lymphocytes (TILs) of melanoma patients than the Melan-A (27-35), but has lower binding affinity and stability than the ELAGIGILTV analog.

Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.

Specifications

Chemistry
Sequence one letter code
  • EAAGIGILTV
Sequence three letter code
  • H-Glu-Ala-Ala-Gly-Ile-Gly-Ile-Leu-Thr-Val-OH
CAS registry number
  • 156251-01-3
Molecular Formula
  • C42H74N10O14
Molecular Mass/ Weight
  • 943.2
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human
Codes
Code Nacres
  • NA.26

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Citations

Profound elevation of CD8+ T cells expressing the intraepithelial lymphocyte marker CD103 (αE/β7 Integrin) in high-grade serous ovarian cancer

Gynecol Oncol . 2010 Jun 11 ; 118(3) 228 | DOI : 10.1016/j.ygyno.2010.05.016

  • J. Webb
  • et al