Peptides

Myristolated PKCz, Pseudosubstrate ZIP, Scrambled - 1 mg

122.00
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  • Cat.Number : AS-63695
  • Availability :
    In stock

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This is a myristoylated peptide used as a control for the pseudosubstrate PKC Zeta. Scrambled ZIP has been used as a control for ZIP as it has identical amino acids as that of ZIP but in an altered sequence that decreases its efficacy by 3- to 4-fold. It has been used in studies to compare the effectiveness or activity of the pseudosubstrate.

Specifications

Chemistry
Sequence one letter code
  • Myr-RLYRKRIWRSAGR
Sequence three letter code
  • Myristoyl-Arg-Leu-Tyr-Arg-Lys-Arg-Ile-Trp-Arg-Ser-Ala-Gly-Arg-OH
Molecular Formula
  • C90H154N30O17
Molecular Mass/ Weight
  • 1928.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Application
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Human, mouse, drosophila, zebrafish, rat
Codes
Code Nacres
  • NA.26

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Citations

Protein kinase C (PKC)ζ pseudosubstrate inhibitor peptide promiscuously binds PKC family isoforms and disrupts conventional PKC targeting and translocation.

Mol Pharmcol . 2015 Jul 21 ; 88(4) 728 | DOI : 10.1124/mol.115.099457.

  • AS. Bogard
  • et al

Zeta inhibitory peptide (ZIP) erases long-term memories in a cockroach.

Neurobiol Learning Memory . 2014 Nov 27 ; 118 89 | DOI : 10.1016/j.nlm.2014.11.011

  • Z. Deng
  • et al

Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism.

J Neurosci . 2015 Apr 22 ; 35(16) 6307 | DOI : 10.1523/JNEUROSCI.3481-14.2015.

  • JV. Kim
  • et al

PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels. Mol Biol

Mol Biol Cell. . 2015 Feb 18 ; 26(8) 1523 | DOI : 10.1091/mbc.E14-12-1613

  • R. Lu
  • et al

Protease activated receptor 2 (PAR2) activation is sufficient to induce the transition to a chronic pain state

Pain . 2015 May 01 ; 156(5) 859 | DOI : 10.1097/j.pain.0000000000000125.

  • DV. Tillu
  • et al

Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neurons.

Neuropharmacol . 2012 Jul 27 ; 64 37 | DOI : 10.1016/j.neuropharm.2012.07.018

  • Y. Yao
  • et al

Inhibiting PKMζ reveals dorsal lateral and dorsal medial striatum store the different memories needed to support adaptive behavior.

Learn. Mem . 2012 Jan 01 ; 19 307 | DOI : 10.1101/lm.025148.111

  • WM. Pauli
  • et al

Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory

J Biol Chem . 2012 Feb 29 ; 287(16) 12879 | DOI : 10.1074/jbc.M112.357244

  • AX. Wu-Zhang
  • et al

PKMζ maintains 1‐day‐and 6‐day‐old long‐term object location but not object identity memory in dorsal hippocampus.

Hippocampus . 2010 Jun 01 ; 20(6) 691 | DOI : 10.1002/hipo.20708

  • O. Hardt
  • et al

PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking.

Nat Neurosci . 2010 Apr 11 ; 13(5) 630 | DOI : 10.1038/nn.2531.

  • P. Migues
  • et al