Peptides

Neurogranin 28-43 [AAKIQASFRGHMARKK], Biotin-LC - 5 mg

592.00
Check your price
  • Cat.Number : AS-27176
  • Availability :
    In stock

Quantity

The native peptide AAKIQASFRGHMARKK (27173) is a synthetic PKC substrate derived from the sequence of neurogranin, a naturally occurring PKC substrate. The peptide is proven to be a PKC substrate with quite good specificity. It is phosphorylated by purified PKC with a Km of 150 nM. No significant phosphorylation of the peptide by either PKA or by CaMK 2 is reported. Substituting Arg36 with Ile causes a significant reduction in the affinity for PKC. Replacing Lys30 with Arg enhances the catalytic efficiency (Vmax/Km) for PKC but diminishes the selectivity of the substrate for PKC. It is generally considered that basic amino acids on both sides of the phosphorylated Ser are important structural determinants in PKC substrates. In addition, the presence of particular basic amino acids (Arg vs Lys) may also contribute to the degree of selectivity of a substrate for PKC.

Specifications

Chemistry
Sequence one letter code
  • Biotin-LC-AAKIQASFRGHMARKK
Sequence three letter code
  • Biotin-LC-Ala-Ala-Lys-Ile-Gln-Ala-Ser-Phe-Arg-Gly-His-Met-Ala-Arg-Lys-Lys-OH
Molecular Formula
  • C94H159N31O20S2
Molecular Mass/ Weight
  • 2139.7
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Application
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human, bovine, mouse
Codes
Code Nacres
  • NA.26

You may also be interested in the following product(s)

Tube of Autocamtide-2 peptide

Autocamtide-2 [KKALRRQETVDAL]

Cat.Number : AS-60249-1
83.00 Excl. Tax
Tube of CREBtide peptide, 5-FAM

CREBtide [KRREILSRRPSYR], 5-FAM labeled

Cat.Number : AS-60436-1
246.00 Excl. Tax