Peptides

NGR Peptide 1 - 1 mg

223,00
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  • Cat.Number : AS-60189-1
  • Availability :
    In stock

Quantity

This is a peptide with NGR (Asn-Gly-Arg) motif having a disulfide bridge connecting cys1 to cys5 known to elicit antimicrobial property in addition to the presence of KLA sequence. This peptide shows potent cytotoxicity and activity against tumor cells due to its binding to CD13 on tumor cells. This peptide shows dose-dependent antiproliferation against tumor cells and induces cell cylce arrest at G2/M phases and apoptosis of the tumor cells. NGR motif containing peptides are useful in delivering cytotoxic drugs, proapoptotic peptides and tumor necrosis factor (TNF) to tumor vasculature.

Specifications

Chemistry
Sequence one letter code
  • CNGRCGGklaklakklaklak-NH2 (Disulfide bridge: 1-5)
Sequence three letter code
  • H-Cys-Asn-Gly-Arg-Cys-Gly-Gly-D-Lys-D-Leu-D-Ala-D-Lys-D-Leu-D-Ala-D-Lys-D-Lys-D-Leu-D-Ala-D-Lys-D-Leu-D-Ala-D-Lys-NH2 (Disulfide bridge: 1-5)
CAS registry number
  • 1926163-30-5
Molecular Formula
  • C94H174N32O22S2
Molecular Mass/ Weight
  • 2170.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Synthetic construct

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