Antibody

OptimAb Anti-5-Methylcytosine (33D3)

407,00
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  • Cat.Number : BI-MECY-0100
  • Availability :
    In stock
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Quantity

Clone 33D3 recognizes the modified base 5-methylcytidine (5-MeCyd) found in plant and vertebrate DNA. It specifically distinguishes 5-MeCyd from its normal DNA base counterpart, cytosine, making it an ideal tool for gene promoter methylation analysis. DNA methylation is a postreplication process involved in the establishment of genomic imprinting, in the control of gene expression and of differentiation. Carcinogenesis is associated with alterations of the DNA methylation pattern: a global DNA hypomethylation is often detected in tumor tissues, associated with local hypermethylation sites. This antibody has been used to detect alterations in the urinary excretion of nucleosides by cancer patients, to visualize the distribution of methyl-rich regions along human chromosomes, to quantify in situ differences between normal and malignant cells from peripheral blood as well as on tissue sections. The antibody is ideal for the histopathological analysis of tissue samples without employing DNA extraction procedures that destroy cells.

Specifications

Modification
Conjugation
  • Unconjugated
Quantity & Purity
Concentration
  • 1 mg/ml
Storage & stability
Form
  • In solution
Storage Buffer
  • PBS + 0.01% Thimerosal
Storage Conditions
  • - 20 °C
Activity
Application
Biomarker Target
Specificity
  • 5-Methylcytosine
Isotype
  • IgG1,l
Clonality
Clone
  • 33D3
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Host
Codes
Code Nacres
  • NA.41