Peptides

Pannexin-1 (Panx1), Mimetic Blocking Peptide - 1 mg

66,00
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  • Cat.Number : AS-61911
  • Availability :
    In production

Quantity

This is a Pannexin-1 (Panx1) mimetic blocking peptide. Pannexin-1 is a recently identified membrane protein that can form gap junction-like connections allowing intercellular passage of dyes when overexpressed in two adjacent oocytes or mammalian epithelial cell lines. Blockade of pannexin-1 in macrophage endogenously expressing the ATP-gated P2X7 receptor (P2X7R) blocks the initial dye uptake, but not the ionic current, and also blocks processing and release of interleukin-1b (IL-1b) in response to P2X7R activation.

Specifications

Chemistry
Sequence one letter code
  • WRQAAFVDSY
Sequence three letter code
  • H-Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr-OH
CAS registry number
  • 955091-53-9
Molecular Formula
  • C58H79N15O16
Molecular Mass/ Weight
  • 1242.4
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Human, mouse, rat

Citations

Neuroinflammation Leads to Region-Dependent Alterations in Astrocyte Gap Junction Communication and Hemichannel Activity.

J Neurosci . 2011 Jan 12 ; 31(2) 414 | DOI : 10.1523/JNEUROSCI.5247-10.2011

  • N. Karpuk
  • et al

Neuroinflammation Leads to Region-Dependent Alterations in Astrocyte Gap Junction Communication and Hemichannel Activity

J Neurosci . 2011 Jan 12 ; 31(2) 414 | DOI : 10.1523/JNEUROSCI.5247-10.2011

  • N. Karpuk
  • et al