Peptides

PKCe Peptide Substrate - 1 mg

132.00
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  • Cat.Number : AS-27183
  • Availability :
    In stock

Quantity

The peptide sequence ERMRPRKRQGSVRRRV corresponds to pseudosubstrate region of the e-isotype of protein kinase C (PKCe) with an alanine to serine substitution. PKCe exhibits an apparent specificity for the native peptide (Km = 68 mM).

Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.

Specifications

Chemistry
Sequence one letter code
  • ERMRPRKRQGSVRRRV
Sequence three letter code
  • Glu-Arg-Met-Arg-Pro-Arg-Lys-Arg-Gln-Gly-Ser-Val-Arg-Arg-Arg-Val
CAS registry number
  • 120253-69-2
Molecular Formula
  • C83H155N39O21S
Molecular Mass/ Weight
  • 2067.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Application
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Zebrafish, Xenopus
Codes
Code Nacres
  • NA.26

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Citations

Inhibition of a secreted glutamic peptidase prevents growth of the fungus Talaromyces emersonii

J Biol Chem. . 2008 Aug 07 ; 283(43) 29186 | DOI : 10.1074/jbc.M802366200

  • AJ. O'Donoghue
  • et al

A homogeneous enzyme fragment complementation-based β-arrestin translocation assay for high-throughput screening of G-protein-coupled receptors

J Biomol Screen. . 2008 Jul 25 ; 13(8) 737 | DOI : 10.1177/1087057108321531

  • X. Zhao
  • et al