Peptides

RGD-4C - 5 mg

1.609,00
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  • Cat.Number : AS-29898
  • Availability :
    In production

Quantity

This peptide, a double cyclic peptide, binds preferentially to integrins at sites of tumor angiogenesis and inflammed synovium in-vivo, and can be internalized into targeted cells.

Specifications

Chemistry
Sequence one letter code
  • ACDCRGDCFCG (Disulfide bridge: 2-10 and 4-8)
Sequence three letter code
  • H-Ala-Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys-Gly-OH (Disulfide bridge: 2-10 and 4-8)
Molecular Formula
  • C42H64N14O16S4
Molecular Mass/ Weight
  • 1149.3
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • synthetic

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Citations

Cell surface profiling with peptide libraries yields ligand arrays that classify breast tumor subtypes

Mol Cancer Ther.  . 2009 May 05 ; 8(5) 1312 | DOI : 10.1158/1535-7163.MCT-08-1105

  • K. Dane
  • et al

Integrin-targeted imaging and therapy with RGD4C-TNF fusion protein.

Mol Cancer Ther. . 2008 May 01 ; 7(5) 1044 | DOI : 10.1158/1535-7163.MCT-07-2084

  • H. Wang
  • et al

Adenoviral‐encoded antigens are presented efficiently by a subset of dendritic cells expressing high levels of αvβ3 integrins

J Leukocyte Bio . 2006 Mar 30 ; 79(6) 1271 | DOI : https://doi.org/10.1189/jlb.1105694

  • A. Harui
  • et al

Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries.

Cancer Res. . 2006 Jan 01 ; 66(1) 34 | DOI : 10.1158/0008-5472.CAN-05-2748

  • MG. Kolonin
  • et al

Targeting Tumor Angiogenesis: Comparison of Peptide and Polymer-Peptide Conjugates

J Nucl Med . 2005 Sep 01 ; 46(9) 1552 | DOI : PMID: 16157540

  • BR. Line
  • et al

Solution Structures and Integrin Binding Activities of an RGD Peptide with Two Isomers

Biochemistry . 2001 Feb 27 ; 40(8) 2373 | DOI : 10.1021/bi002101f

  • N. Munt
  • et al