SensoLyte® 390 ACE2 Activity Assay Kit Fluorimetric - 1 kit

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  • Cat.Number : AS-72086
  • Availability :
    In stock
  • Shipping conditions : Ice delivery fees must be applied


ACE2 or ACEH, angiotensin-converting enzyme 2, a homolog of angiotensin-converting enzyme, is a zinc metallopeptidase with specificity, tissue distribution, and function distinct from those of ACE. ACE2 may play a unique role in the renin-angiotensin system and mediate cardiovascular and renal functions.
The SensoLyte® 390 ACE2 Activity Assay Kit provides a convenient assay for high throughput screening of ACE2 enzyme inhibitors and inducers using a Mc-Ala/Dnp fluorescence resonance energy transfer (FRET) peptide. In the FRET peptide, the fluorescence of Mc-Ala is quenched by Dnp. Upon cleavage into two separate fragments by ACE2, the fluorescence of Mc-Ala is recovered, and can be monitored at excitation/emission = 330/390 nm. This assay can detect the activity of subnanogram level of ACE2. Assays are performed in a convenient 96-well microplate format.


Kits components
  • Component A: Mca/Dnp, ACE2 substrate, Ex/Em=330 nm/390 nm upon cleavage: 5 mM, 50µL Component B: Mca fluorescence reference standard, Ex/Em=330 nm /390 nm: 1 mM, 10 µL Component C: Assay Buffer: 20 mL Component D: Inhibitor of ACE2: 100 µM, 10 µL Component E: Stop Solution: 10 mL
UniProt number
  • Q9BYF1
Absorbance (nm)
  • 330
Emission (nm)
  • 390
Storage & stability
Storage Conditions
  • Store all components at -20°C. Component C and E can be stored at room temperature for convenience. Protect components A and B from light and moisture.
Biomarker Target
Detection Method
Detection Limit
  • subnanogram
Research Area
Sub-category Research Area
  • Research use
Code Nacres
  • NA.32

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Activities of angiotensin-converting enzymes ACE1 and ACE2 and inhibition by bioactive peptides in porcine ocular tissues

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