Proteolipid protein (PLP) is the most abundant protein in the central nervous system (CNS) myelin sheath and is highly conserved among species. PLP has a 50% hydrophobic amino acids content and a molecular weight of 30 kDa. Mouse PLP (178-191) is able to induce autoantibody production and relapsing-remitting neurological disease causing extensive plaque-like demyelination. Autoantibody response to mouse PLP (171-191) has been observed in induced experimental autoimmune encephalomyelitis (EAE) in B10.PL, SJL, C57BL/6, F1, and BALB/c mice strains. However, the exact pathological role and action of anti-mouse PLP (178-191) autoantibody is not well understood.
The SensoLyte® Anti-PLP (178-191) IgG Quantitative ELISA Kit (mouse) provides a convenient and quantitative assay for anti-PLP (178-191) autoantibody in mouse. This kit is useful to researchers who want to determinine the amount of anti-PLP (178-191) antibody present in biological samples, and can help provide information on the role it plays in the development and treatment of EAE, an animal model for MS pathogenesis.