ß-Amyloid (1-42), HiLexa Fluor™ 488-labeled - 0.1 mg

Aß (1-42), a major component of amyloid plaques, accumulates in neurons of Alzheimer’s disease brains. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Aß (1-42) is the principal species associated with senile plaque amyloids, while Aß (1-40) is more abundant in cerebrovascular amyloid deposit.


This is a fluorescent (HiLexa™ Fluor 488) labeled ß-Amyloid peptide, Abs/Em=503/528 nm. HiLexa 488™ Fluor labeled Aß (1-42) offers brighter intensity with high fluorescence quantum yield and photostability suitable for pH-insensitive applications including flow cytometry and imaging. HiLexa™ Fluor 488 is the same structure as that of Alexa® Fluor 488.

HiLexa™ Fluor 488 labeled ß-Amyloid peptide can be used in studies applicable for monitoring aggregation kinetics of Aβ via steady-state fluorescence, measuring amyloid aggregates in cellular compartments in live neurons via confocal microscopy, quantification of Aβ(1-42) by flow cytometry upon cellular uptake, monitoring Aβ fibrillogenesis via fluorescence correlation spectroscopy, assaying Aβ degradation, evaluating role of autophagy in cell lines via immunoblotting, in vitro phagocytosis assay to determine uptake efficacy by macrophages, and a host of other applications including immunocytochemistry, RT-PCR etc.

Specifications

Downloads