- Occurs between N-terminus to C-terminus.
- Via Amide bond formation (lactamization).
- Most frequently used cyclization conferring greater stability.
Occurs between N-terminus and an internal COOH
(e.g. the ß-COOH-group of Asp or γ-COOH-group of Glu).
Occurs between internal NH2s and C-terminus
(e.g. the ε-NH2–group of Lys).
Occurs between Side chain of Lysine (ε-NH2–group of Lys)
to Aspartic or Glutamic acid (γ-COOH-group).
Head‐to‐Tail Cyclic Peptide Inhibitors of the Interaction between Human von Willebrand Factor and Collagen.
The study examined novel cyclic peptides as moderate inhibitors of the protein–protein interaction between von Willebrand factor (vWF) and collagen that initiates blood clot formation.
‘All of the head‐to‐tail cyclic peptides, was purchased and synthesized by AnaSpec (Eurogentec's US subsidiary).‘
- Length: 5-15 amino acids.
- Purity: ≥95%, ≥90%, ≥85%, ≥70% or crude
- Quantity: 1 mg minimum up to gram quantities, delivered as gross weight or net weight.
- Improved binding affinity to targets
- Modulation of protein-protein interactions (PPIs)
- Membrane permeability
- Metabolic stability & bioavailability