Peptides

390 MMP Substrate 13, NFF-3 - 1 mg

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  • Cat.Number : AS-27114
  • Availability :
    In stock

Quantity

Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
NFF-3 is hydrolyzed rapidly by MMP-3 (kcat/Km = 218,000 s-1 M-1) and very slowly by MMP-9 (kcat/Km = 10,100 s-1 M-1), but no significant hydrolysis by MMP-1 and MMP-2. It is one of the few synthetic substrates selectively hydrolyzed by certain members of the MMP family and thus has important applications for the differentiation of MMP-3 activity from that of other MMPs. Abs/Em = 325/393 nm.

Specifications

Chemistry
Sequence one letter code
  • Mca-RPKPVE-Nva-WR-K(Dnp)-NH2
Sequence three letter code
  • Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2
CAS registry number
  • 158584-09-9
Molecular Formula
  • C78H110N22O20
Molecular Mass/ Weight
  • 1675.9
Properties
Absorbance (nm)
  • 325
Emission (nm)
  • 393
Modification
Conjugation type
  • Double dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use

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