Oligos

5' MeO-Cl-Acridine - 1 modification

105,00
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  • Cat.Number : MD-CN050-05004
  • Availability :
    In production

Select specification

Synthesis scale

Oligos bearing the 6-chloro-2-methoxyacridine molecule at either terminus or within their sequence have the ability to intercalate efficiently into a double helix. Covalent binding of MeO-Cl-Acridine therefore increases hybrid stability by providing additional binding energy. Acridine-labelled oligos can thus be used in applications where increased stability of oligonucleotide hybrids is crucial. Adding the dye to the 3’terminus also protects the oligo from exonuclease degradation.

These oligos also possess the ability to form triplex helices, and, due to their relative hydrophobicity, to pass through membranes more easily than unmodified oligonucleotides.

Specifications

Chemistry
Molecular Mass/ Weight
  • 450,86
Modification
Modification Position
  • 5'
Storage & stability
Resuspension condition
  • - Spin the tube briefly to collect the pellet in the bottom of the tube - Add an appropriate volume of recommended buffer (refer to technical data sheet) - Allow the tube to stand a few minutes - Vortex the tube for 15 seconds
Storage Conditions
  • Dried Oligonucleotides are stable for 18 months at ambiant temperature. Oligonucleotides in solutions are stable for 24 months at -20°C. (Tolerance -20°C± 5°C. ) For more information please refer to the Reconstitution-Storage-Stability page
Activity
Usage
  • Research use

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