Peptides

520 MMP FRET Substrate 14 - 0.1 mg

214.00
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  • Cat.Number : AS-60581-01
  • Availability :
    In stock

Quantity

Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This peptide is a sensitive substrate for assaying MMP-1, 2, 3, 7, 8, 9, 12, and 13 activities, Abs/Em = 494/521 nm.

Specifications

Chemistry
Sequence one letter code
  • QXL® 520 -γ-Abu-P-Cha-Abu-Smc-HA-Dab(5-FAM)-AK-NH2 (Smc=S-Methyl-L-cysteine)
Sequence three letter code
  • QXL® 520 -γ-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 (Smc=S-Methyl-L-cysteine)
Molecular Mass/ Weight
  • 1912.1
Properties
Absorbance (nm)
  • 494
Emission (nm)
  • 521
Modification
Conjugation type
  • Double dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Codes
Code Nacres
  • NA.26

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Citations

Excessive activity of cathepsin K is associated with cartilage defects in a zebrafish model of mucolipidosis II.

Dis Models Mech . 2011 Nov 01 ; 5(2) 177 | DOI : 10.1242/dmm.008219

  • A.C. Petrey
  • et al