Peptides

520 MMP FRET Substrate 6 - 0.1 mg

162,00
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  • Cat.Number : AS-60573-01
  • Availability :
    In stock

Quantity

Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This peptide is a sensitive substrate for assaying MMP-2 and 13 activities, Abs/Em = 494/521 nm.

Specifications

Chemistry
Sequence one letter code
  • QXL® 520-PLGMWSRK(5-FAM)-NH2
Sequence three letter code
  • QXL® 520-Pro-Leu-Gly-Met-Trp-Ser-Arg-Lys(5-FAM)-NH2
Molecular Mass/ Weight
  • 1822.9
Properties
Absorbance (nm)
  • 494
Emission (nm)
  • 521
Modification
Conjugation type
  • Double dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use

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Citations

Divergent role for MMP-2 in myelin breakdown and oligodendrocyte death following transient global ischemia.

J Neurosci Res . 2010 Mar 01 ; 88(4) 764 | DOI : 10.1002/jnr.22257

  • E. Walker
  • et al