Peptides

ADAMTS-4/Aggrecanase FRET Substrate, WAAG-3R - 1 mg

223,00
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  • Cat.Number : AS-60431-1
  • Availability :
    In stock

Quantity

Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage.
This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) assay. Ex/Em = 340/420 nm.

Specifications

Chemistry
Sequence one letter code
  • Abz-TEGEARGSVI-Dap(Dnp)-KK-NH2
Sequence three letter code
  • Abz-Thr-Glu-Gly-Glu-Ala-Arg-Gly-Ser-Val-Ile-Dap(Dnp)-Lys-Lys-NH2
Molecular Formula
  • C69H109N23O24
Molecular Mass/ Weight
  • 1644.8
Properties
Absorbance (nm)
  • 340
Emission (nm)
  • 420
Modification
Conjugation type
  • Double dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

The Design and Synthesis of Novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis

Bioorg Med Chem Lett. . 2011 Jan 18 ; 21(5) 1376 | DOI : 10.1016/j.bmcl.2011.01.036

  • C. Savi
  • et al