Amyloid Bri (1-23) and Amyloid Bri (1-34) peptides are post-translational products of mutated BRI2 gene. Amyloid Bri peptides are found as plaques in brains of patients with Familiar British Dementia (FBD) that shares many common features with Alzheimer’s Disease.
Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.