Amyloid Bri (1-23) and Amyloid Bri (1-34) peptides are post-translational products of the mutated BRI2 gene. Amyloid Bri peptides are found as plaques in the brains of patients with Familiar British Dementia (FBD), a condition that shares many common features with Alzheimer’s Disease.
Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.