Peptides

Calpain Substrate, Fluorogenic, (Z-AA)2Rh110 - 5 mg

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  • Cat.Number : AS-60320-5
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(Z-Ala-Ala)2Rh110 is a very sensitive fluorogenic calpain substrate. In general, Rh110-based protease substrates are much more sensitive than the analogous AMC/AFC-based substrate. This enhanced sensitivity might be attributed to the greater fluorescence of the enzymatic product. The colorless and nonfluorescent (Z-Ala-Ala)2Rh110 is hydrolyzed to highly fluorescent rhodamine 110, which exhibits excellent spectral properties that match the optimal detection window of most fluorescence instruments. Alternatively, (Z-Ala-Ala)2Rh110 can also be used to detect calpain in a chromogenic mode since the enzymatic product (rhodamine 110) exhibits a large extinction coefficient (close to 100,000 cm-1mol-1). Abs/Em = 497/527 nm

Specifications

Chemistry
Sequence one letter code
  • (Z-AA)2Rh110
Sequence three letter code
  • (Z-Ala-Ala)2Rh110
Molecular Formula
  • C48H47ClN6O11
Molecular Mass/ Weight
  • 919.4
Properties
Absorbance (nm)
  • 497
Emission (nm)
  • 527
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Synthetic construct

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