Peptides

Caspase 8 Substrate 1, chromogenic - 5 mg

100.00
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  • Cat.Number : AS-25258-5
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Caspase-8 substrate with Km = 66 uM; Substrate for granzyme B;
pNA (4-nitroaniline)-derived caspase substrates are widely used for the colorimetric detection of various caspase activities. Cleavage of pNA peptides by caspases generates pNA that is monitored colorimetrically at ~405 nm. pNA has maximum absorption around 408 nm.

Specifications

Chemistry
Sequence one letter code
  • Ac-IETD-pNA
Sequence three letter code
  • Ac - Ile-Glu-Thr-Asp - pNA
CAS registry number
  • 219138-21-3
Molecular Formula
  • C27H38N6O12
Molecular Mass/ Weight
  • 638.7
Properties
Absorbance (nm)
  • 408
Modification
Conjugation type
  • Conjugates
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Codes
Code Nacres
  • NA.26

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Citations

Arsenic and fluoride induce neural progenitor cell apoptosis.

Toxicol Lett . 2011 Mar 23 ; 203(3) 237 | DOI : 10.1016/j.toxlet.2011.03.023.

  • R. Rocha
  • et al

E1A sensitizes cancer cells to TRAIL-induced apoptosis through enhancement of caspase activation.

Mol Cancer Res . 2005 Apr 01 ; 3(4) 219 | DOI : 10.1158/1541-7786.MCR-04-0084

  • R. Shao
  • et al

Synergism of Rana catesbeiana ribonuclease and IFN-γ triggers distinct death machineries in different human cancer cells.

FEBS Lett . 2005 Jan 03 ; 579(1) 265 | DOI : 10.1016/j.febslet.2004.11.086

  • C-HA. Tang
  • et al