Peptides

CSP-2, Competence-Stimulating Peptide-2 - 1 mg

105.00
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  • Cat.Number : AS-63877
  • Availability :
    In stock

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Genetic transformation in Streptococcus pneumoniae, Streptococcus mitis and Streptococcus oralis is regulated by secreted peptide pheromones named the competence-stimulating peptide (CSP). Different strains and species of these bacteria produce CSP with different primary sequence. They are termed pheromones CSP-1 (EMRLSKFFRDFILQRKK), CSP-2 (EMRISRIILDFLFLRKK), CSP-153 (DKRLPYFFKHLFSNRTK), CSP-612 (ESRLSRLLRDFIFQIKQ), CSP-676 (ERRIPDVIRSLLFQKRK), and CSP-12261 (EIRQTHNIFFNFFKRR).

Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.

Specifications

Chemistry
Sequence one letter code
  • EMRISRIILDFLFLRKK
Sequence three letter code
  • H-Glu-Met-Arg-Ile-Ser-Arg-Ile-Ile-Leu-Asp-Phe-Leu-Phe-Leu-Arg-Lys-Lys-OH
Molecular Formula
  • C101H172N28O23S1
Molecular Mass/ Weight
  • 2178.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • streptococcus
Codes
Code Nacres
  • NA.26

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Citations

Designed reduction of Streptococcus pneumoniae pathogenicity via synthetic changes in virulence factor codon-pair bias.

J Infect Dis . 2011 Feb 21 ; 203(9) 1264 | DOI : 10.1093/infdis/jir010

  • J. Coleman
  • et al