Insulin B (9-23) - 1 mg
- Cat.Number : AS-61532
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This insulin B-chain peptide binds to a class II histocompatibility complex (MHC) allele called I-Ag7. A number of autoimmune diseases has been linked to class II proteins encoded by the MHC. Type 1 diabetes, or insulin-dependent diabetes mellitus, is a T cell-mediated disease that results in autoimmune destruction of pancreatic ß cells leading to hyperglycemia. This insulin B peptide may be a self-antigen candidate that could initiate the disease. Immunization with this peptide in mice led to autoantibodies and insulitis.
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Citations
Cutting Edge: immunosuppressant as adjuvant for tolerogenic immunization
J Immunol. . 2008 Apr 15 ; 180(8) 5172 | DOI : 10.4049/jimmunol.180.8.5172
- Y. Kang
- et al
Enhanced trafficking to the pancreatic lymph nodes and auto-antigen presentation capacity distinguishes peritoneal B lymphocytes in non-obese diabetic mice.
Diabetologia . 2009 Nov 22 ; 53(2) 346 | DOI : 10.1007/s00125-009-1599-x
- S. Alam
- et al
Inflammatory Tendencies and overproduction of IL-17 in the colon of young NOD mice are counteracted with diet change.
Diabetes . 2010 Jun 14 ; 59(9) 2237 | DOI : 10.2337/db10-0147
- C. Alam
- et al