Peptides

IRBP (1-20), human - 1 mg

112,00
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  • Cat.Number : AS-62297
  • Availability :
    In stock

Quantity

This peptide is a 1 to 20 amino acid fragment of the interphotoreceptor retinoid binding protein (IRBP). IRBP is a 140-kDa glycolipoprotein residing in the interphotoreceptor matrix between the neural retina and the retinal pigment epithelium. Human IRBP peptide 1-20 contains a major epitope for the H-2b haplotype. Immunization with IRBP (1 – 20) induces T-cell–mediated experimental autoimmune uveoretinitis (EAU) disease. The pathology of disease induced by the peptide, or by adoptive transfer of cells specific to the peptide, is similar to that induced by the whole IRBP protein.

Specifications

Chemistry
Sequence one letter code
  • GPTHLFQPSLVLDMAKVLLD
Sequence three letter code
  • H-Gly-Pro-Thr-His-Leu-Phe-Gln-Pro-Ser-Leu-Val-Leu-Asp-Met-Ala-Lys-Val-Leu-Leu-Asp-OH
Molecular Formula
  • C101H164N24O28S1
Molecular Mass/ Weight
  • 2194.6
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Role of DAF in protecting against T-cell autoreactivity that leads to experimental autoimmune uveitis.

Invest Ophthalmol Vis Sci. . 2009 May 14 ; 50(8) 3778 | DOI : 10.1167/iovs.08-3264

  • F. An
  • et al

A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice

J Clin Invest. . 2003 Apr 15 ; 111(8) 1171 | DOI : 10.1172/JCI200315155

  • G. Pennesi
  • et al