Peptides

IRBP, Interphotoreceptor Retinoid Binding Protein Fragment

112,00
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  • Cat.Number : AS-60183-1
  • Availability :
    In stock

Size

Quantity

This 20-residue peptide, a major pathogenic T-cell epitope (161–180), is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP). It has been shown to induce posterior uveitis (EAU).

Specifications

Chemistry
Sequence one letter code
  • SGIPYIISYLHPGNTILHVD
Sequence three letter code
  • H-Ser-Gly-Ile-Pro-Tyr-Ile-Ile-Ser-Tyr-Leu-His-Pro-Gly-Asn-Thr-Ile-Leu-His-Val-Asp-OH
Molecular Formula
  • C103H157N25O29
Molecular Mass/ Weight
  • 2209.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human, macaque

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Citations

Low dose rapamycin exacerbates autoimmune experimental uveitis.

Plos One . 2012 May 04 ; 7(5) e36589 | DOI : 10.1371/journal.pone.0036589

  • Z. Zhang
  • et al

Role of DAF in protecting against T-cell autoreactivity that leads to experimental autoimmune uveitis.

Invest Ophthalmol Vis Sci. . 2009 May 14 ; 50(8) 3778 | DOI : 10.1167/iovs.08-3264

  • F. An
  • et al

Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: initial encounter with autoantigen defines disease phenotype.

J Immunol. . 2007 May 01 ; 178(9) 5578 | DOI : 10.4049/jimmunol.178.9.5578

  • Jung Tan
  • et al