This 20-residue peptide, a major pathogenic T-cell epitope (161–180), is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP). It has been shown to induce posterior uveitis (EAU).
Plos One . 2012 May 04 ;
7(5) e36589 |DOI : 10.1371/journal.pone.0036589
Role of DAF in protecting against T-cell autoreactivity that leads to experimental autoimmune uveitis.
Invest Ophthalmol Vis Sci. . 2009 May 14 ;
50(8) 3778 |DOI : 10.1167/iovs.08-3264
Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: initial encounter with autoantigen defines disease phenotype.