[Lys(Me2)4]-Histone H3 (1-21) - 1 mg
- Cat.Number : AS-63677
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This is a dimethylated lysine at position 4 of the 1-21 amino acid histone H3 peptide. This form of histone methylation is characterized as being enriched around transcription start sites (TSS). It has been observed that a subgroup of genes linked to T cell functions showed high levels of H3K4me2 within their gene body. While enrichment for H3K4me2 within the gene body is a characteristic trait of expressed genes in yeast, in contrast, H3K4me2 has been shown to be predominantly enriched around the TSS in mammals.
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Citations
Measurement of lysine-specific demethylase-1 activity in the nuclear extracts by flow-injection based time-of-flight mass spectrometry.
J Clin Biochem Nutr . 2015 Feb 13 ; 56(2) 123 | DOI : 10.3164/jcbn.14-99
- C. Sakane
- et al