[Lys(Me3)36]-Histone H3 (21-44)-GK(Biotin)
- Cat.Number : AS-64441-025
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This is a Histone 3 peptide trimethylated at lysine 36. It's role has been indicative of defining exons, as certain nucleosome-enriched exons are observed to be enriched in some histone modifications. It is belived that this pattern of modification as seen with this H3K36me3 peptide, influences alternative splicing, perhaps by signaling effector proteins to mark particular exons for inclusion in the final transcript as they exit the RNA Polymerase II complex. It has also been shown in yeast that H3K36me3 gets deposited on histones as they are displaced by RNA polymerase II (RNAPII) during transcription. H3K36me3 then serves as a mark for HDACs to bind and deacetylate the histones.
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Citations
Selective recognition of H3.1K36 dimethylation/H4K16 acetylation facilitates the regulation of all-trans-retinoic acid (ATRA)-responsive genes by putative chromatin reader ZMYND8
J. Biol. Chem. . 2015 Dec 11 ; 291(6) 2664 | DOI : 10.1074/jbc.M115.679985
- S. Adhikary
- et al
Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing.
PLOS Genet . 2012 May 17 ; 8(5) e1002717 | DOI : 10.1371/journal.pgen.1002717
- MM. Pradeepa
- et al