Peptides

Renin FRET Substrate (5-FAM/QXL™520), rat - 0.1 mg

209,00
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  • Cat.Number : AS-62334-01
  • Availability :
    In stock

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Quantity

This renin FRET peptide is a specific substrate for rat renin. Aspartyl protease cleaves angiotensinogen to yield angiotensin I, which is further converted to angiotensin II. The renin-angiotensin system is a coordinated hormonal cascade in the control of cardiovascular, renal, and adrenal function. It governs body fluid and electrolyte balance, as well as arterial pressure. Since an overactive renin-angiotensin system leads to hypertension, renin is an attractive target for the treatment of this disease. This renin peptide substrate may be used for screening renin inhibitors. In the FRET peptide, the fluorescence of 5-FAM is quenched by QXL® 520. Upon cleavage into two separate fragments by rat renin, the fluorescence of 5-FAM is recovered, and can be monitored at excitation/emission = 490/520 nm. The SensoLyte® 520 Renin Assay Kit (cat # 72040) contains the human renin FRET substrate.

Specifications

Chemistry
Molecular Mass/ Weight
  • 2194.4
Properties
Absorbance (nm)
  • 490
Emission (nm)
  • 520
Modification
Conjugation type
  • Double dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Codes
Code Nacres
  • NA.26

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Citations

Feasibility of fluorescence energy transfer system for imaging the renoprotective effects of aliskiren in diabetic mice

J Renin Angiotensin Aldosterone Syst . 2016 May 23 ; 17(2) 1470320315625700 | DOI : 10.1177/1470320315625704

  • K. Kidokoro
  • et al

Modulation of the angiogenic phenotype of normal Systemic Sclerosis endothelial cells by gain-loss of function of PTX3 MMP12

Arthritis Rheum. . 2010 Aug 01 ; 62(8) 2488 | DOI : 10.1002/art.27522

  • F. Margheri
  • et al

Multiphoton imaging of renal regulatory mechanisms

Physiology (Bethesda). . 2009 Apr 01 ; 24 88 | DOI : 10.1152/physiol.00001.2009

  • J. Peti-Peterdi
  • et al

Connexin45 is expressed in the juxtaglomerular apparatus and is involved in the regulation of renin secretion and blood pressure

Am J Physiol Regul Integr Comp Physiol.  . 2008 Jun 25 ; 295(2) R371 | DOI : 10.1152/ajpregu.00468.2007

  • F. Hanner
  • et al