Renin FRET Substrate (5-FAM/QXL® 520), rat - 0.1 mg
- Cat.Number : AS-62334-01
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This renin FRET peptide is a specific substrate for rat renin. Aspartyl protease cleaves angiotensinogen to yield angiotensin I, which is further converted to angiotensin II. The renin-angiotensin system is a coordinated hormonal cascade in the control of cardiovascular, renal, and adrenal function. It governs body fluid and electrolyte balance, as well as arterial pressure. Since an overactive renin-angiotensin system leads to hypertension, renin is an attractive target for the treatment of this disease. This renin peptide substrate may be used for screening renin inhibitors. In the FRET peptide, the fluorescence of 5-FAM is quenched by QXL® 520. Upon cleavage into two separate fragments by rat renin, the fluorescence of 5-FAM is recovered, and can be monitored at excitation/emission = 490/520 nm. The SensoLyte® 520 Renin Assay Kit (cat # 72040) contains the human renin FRET substrate.
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Citations
Feasibility of fluorescence energy transfer system for imaging the renoprotective effects of aliskiren in diabetic mice
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- et al
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- et al
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Physiology (Bethesda). . 2009 Apr 01 ; 24 88 | DOI : 10.1152/physiol.00001.2009
- J. Peti-Peterdi
- et al
Connexin45 is expressed in the juxtaglomerular apparatus and is involved in the regulation of renin secretion and blood pressure
Am J Physiol Regul Integr Comp Physiol. . 2008 Jun 25 ; 295(2) R371 | DOI : 10.1152/ajpregu.00468.2007
- F. Hanner
- et al