Adrenomedullin Peptides

Role of Adrenomedullin

It plays an important role in physiological regulation of circulation, having a potent hypotensive effect when infused into circulation.

It increases cardiac contractility, dilates coronary arteries and modulates stretch-induced ANP (atrial natriuretic peptide) release.

AM is up-regulated under various pathophysiological conditions, such as myocardial ischemia, systemic inflammatory response syndrome, hemorrhagic and endotoxic hock, chronic hypotension in hemodialysis, cirrhosis and pulmonary hypertension.


  • Prigent, M. et al. J Cell Biol 163, 1111 (2003)
  • Mittra, S. et al. Am J Physiol Heart Circ Physiol 286, H1034 (2004)
  • Champion, HC. et al. Am J Physiol 272, R234 (1997)
  • Hay, DL. et al. Br J Pharmacol 140, 477 (2003)
  • Kinnunen, P. Adrenomedullin as a Regulator of Cardiac Function. Oulu Finland (2000)
  • Ziolkowska, A. et al. Int J Mol Med 11, 613 (2003)
  • Nishimatsu, H. et al. Hypertens Res 26 Suppl, S79 (2003)
  • Hyvelin, JM. et al. J Card Surg Jul, 17328 (2002)
  • Kinnenun, P. et al. Biochem Biophys Res Commun 192, 553 (1993)
  • Mahata, M. et al. Hypertension 32, 907 (1998)

More about Adrenomedullin

Adrenomedullin (AM) is a 52 amino acid vasoactive peptide discovered in 1993.

Member of the calcitonin family of peptides, it shares sequence homology with the calcitonin gene-related peptide (CGRP) and peptides from the pancreatic amylin family.

cDNA sequences of rat, pig and human reveal that preproadrenomedullin consists of 185 amino acids, with 3 sites of paired basic amino acids as targets for prohormone-processing proteolytic cleavage.

AM is produced by several tissues, including adrenal medulla, lung, kidney, retinal pigment epithelium, neurons, astrocytes, vascular endothelium, vascular smooth muscle cells and heart.