Role of Adrenomedullin
It plays an important role in physiological regulation of circulation, having a potent hypotensive effect when infused into circulation.
It increases cardiac contractility, dilates coronary arteries and modulates stretch-induced ANP (atrial natriuretic peptide) release.
AM is up-regulated under various pathophysiological conditions, such as myocardial ischemia, systemic inflammatory response syndrome, hemorrhagic and endotoxic hock, chronic hypotension in hemodialysis, cirrhosis and pulmonary hypertension.
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More about Adrenomedullin
Adrenomedullin (AM) is a 52 amino acid vasoactive peptide discovered in 1993.
Member of the calcitonin family of peptides, it shares sequence homology with the calcitonin gene-related peptide (CGRP) and peptides from the pancreatic amylin family.
cDNA sequences of rat, pig and human reveal that preproadrenomedullin consists of 185 amino acids, with 3 sites of paired basic amino acids as targets for prohormone-processing proteolytic cleavage.
AM is produced by several tissues, including adrenal medulla, lung, kidney, retinal pigment epithelium, neurons, astrocytes, vascular endothelium, vascular smooth muscle cells and heart.