Peptides

[Ala13]-Apelin-13 - 1 mg

86,00
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  • Cat.Number : AS-61078
  • Availability :
    In stock

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Apelin is the endogenous ligand for the G-protein-coupled APJ receptor. It is produced as a pre-proprotein of 77 amino acids. Upon signal peptide cleavage, the proprotein of 55 amino acids may generate several active fragments: Apelin-36 (36 aa corresponding to the sequence 42-77), Apelin-17 (17 aa corresponding to the sequence 61-77) and Apelin-13 (13 aa corresponding to the sequence 65-77).
Apelin -13 is a vasoactive peptide and one of the most potent endogenous inotropic agents known. It is one of the active peptide fragments resulting from maturation of preproapelin. It is suggested that Apelin-13 could be a competitive agonist to the apelin receptor, which is a class A G-protein coupled receptor and is a putative target for treatment of cardiovascular and metabolic diseases. Apelin-13 may undergo a pyroglutamylation at its N-terminal glutamine residue.

Specifications

Chemistry
Sequence one letter code
  • QRPRLSHKGPMPA
Sequence three letter code
  • H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala-OH
CAS registry number
  • 568565-11-7
Molecular Formula
  • C63H107N23O16S
Molecular Mass/ Weight
  • 1474.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human, mouse, bovine, rat

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