Peptides

Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled - 0.5 mg

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  • Cat.Number : AS-23972
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    In stock

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A-type (Atrial) natriuretic peptide (ANP), also called Cardiodilatine (CDD), is a peptide hormone composed of 28 amino acids. It is processed from a 151aa prepro-ANP by signal peptide removal, followed by specific protease cleavage by corin of the pro-ANP. The 28a C-terminal peptide hormone contains a 17aa ring formed by a disulfide bridge between Cys7 and Cys23. and a tail. It is produced in cardiac myocytes, where it exerts vasodilating effects, hence playing an important role in the regulation of blood pressure and natriuresis/diuresis. Residues Phe8, Arg14 and the C-terminal sequence of ANP are known to bind to human NPR-A (Natriuretic peptide receptor type A). ANP is closely related to BNP (brain natriuretic peptide) and CNP (C-type natriuretic peptide), which share a similar ring structure.
This ANP (1-28) peptide hormone has been biotinylated at the N-terminus and can be used in conjugation experiments.

Specifications

Chemistry
Sequence one letter code
  • Biotin-SLRRSSCFGGRMDRIGAQSGLGCNSFRY (Disulfide bridge: 7-23)
Sequence three letter code
  • Biotin-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bridge: 7-23)
CAS registry number
  • 1815618-06-4
Molecular Formula
  • C137H217N47O41S4
Molecular Mass/ Weight
  • 3308.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Human, Porcine
Codes
Code Nacres
  • NA.26

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