Peptides

B-type Natriuretic Peptide, BNP-45, mouse - 0.5 mg

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  • Cat.Number : AS-61152
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BNP-45 represents the 45 amino acids at the C-terminus and the mouse BNP-45 has all the amino acid residues thought essential for NP bioactivity, although sequence identity when studied with other BNP hormones (rat, 64%; dog, 53%; pig, 50%; and human, 44%) was clearly less than the identity among ANF hormones. Further, sequence identity between rat and mouse BNP prohormones is found to be more conserved in the N-terminal portion of the prohormone than in the C-terminal BNP-45 (88% versus 64%). A protein kinase C phosphorylation site is found to be present in the putative mature mouse BNP-45 hormone at threonine 81. Comparing the amino acid sequence surrounding the proteolytic processing site for BNP-32 in human, pig, and dog BNP with the corresponding site for BNP-45 in the rat and mouse sequence we find that all of the secreted BNP hormones have an N-terminal serine preceded by an arginine in the prohormone sequence, and the mouse and rat sequences are highly conserved at the putative scissile bond (LKRVLR-SQ). Further comparative sequence analysis indicates that an arginine being present at position -4 relative to the scissile (R-S) bond in all mammalian BNP precursors. Thus, processing of BNP prohormones to both BNP-45 in rodents and BNP-32 in higher mammals appears to require a protease with a conserved recognition sequence (RXXR-S). Also, the conserved sequences in the BNP prohormones matches the consensus cleavage site for human furin, a calcium-dependent serine endoprotease expressed in mouse heart, and possibly having a role in processing BNP precursors.

Specifications

Chemistry
Sequence one letter code
  • SQGSTLRVQQRPQNSKVTHISSCFGHKIDRIGSVSRLGCNALKLL (Disulfide bridge:23-39)
Sequence three letter code
  • H-Ser-Gln-Gly-Ser-Thr-Leu-Arg-Val-Gln-Gln-Arg-Pro-Gln-Asn-Ser-Lys-Val-Thr-His-Ile-Ser-Ser-Cys-Phe-Gly-His-Lys-Ile-Asp-Arg-Ile-Gly-Ser-Val-Ser-Arg-Leu-Gly-Cys-Asn-Ala-Leu-Lys-Leu-Leu-OH (Disulfide bridge:23-39)
CAS registry number
  • 1816939-52-2
Molecular Formula
  • C209H354N70O63S2
Molecular Mass/ Weight
  • 4919.9
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • mouse
Codes
Code Nacres
  • NA.26

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